BNT162b2 mRNA COVID-19 vaccine effectiveness amongst Italian healthcare staff

The continued coronavirus illness 2019 (COVID-19) pandemic has been attributable to the fast outbreak of the extreme acute respiratory coronavirus 2 (SARS-CoV-2). Scientists have developed novel vaccines, and vaccination applications have commenced in lots of international locations. In Italy, this system began in December 2020, and the out there vaccine was the BNT162b2 mRNA vaccine (Cominarty).

Study: BNT162b2 mRNA COVID-19 Vaccine Effectiveness in the Prevention of SARS-CoV-2 Infection and Symptomatic Disease in Five-Month Follow-Up: A Retrospective Cohort Study. Image Credit: cortex-film/ ShutterstockExamine: BNT162b2 mRNA COVID-19 Vaccine Effectiveness within the Prevention of SARS-CoV-2 An infection and Symptomatic Illness in 5-Month Observe-Up: A Retrospective Cohort Examine. Picture Credit score: cortex-film/ Shutterstock

A brand new research has been printed in Vaccines that evaluated the effectiveness of Cominarty towards documented SARS-CoV-2 an infection and symptomatic illnesses within the medium to long run.

A new study

A mass vaccination marketing campaign was initiated in Italy and different European international locations on December 27, 2020. Healthcare staff (HCWs) have been prioritized for vaccination by the Italian authorities as they have been at excessive danger of contracting the virus. The vaccine was administered to people 12 years of age and older, a minimum of 21 days aside. Within the pre-licensure trial, the vaccine (Pfizer-BioNTech) was 95% efficient in stopping COVID-19 and didn’t have any vital uncomfortable side effects.

The cohort research was carried out at Bari Policlinico Normal College Hospital, comprising 1000 beds and 6000 well being care staff (HCWs). HCWs who accomplished the vaccination schedule have been matched with HCWs who had refused vaccination, and the 2 teams have been adopted up for 5 months (January–Might 2021). The medium- to long-term effectiveness of BNT162b2 was evaluated.

The research inhabitants comprised 6136 HCWs, out of which 5351 have been within the vaccinated group. The median time between the primary and second doses was 23 days. The outcomes obtained for this inhabitants have been in comparison with these of a earlier report by the identical authors, which was carried out in Apulia (with about 4,000,000 inhabitants). In Apulia, from February 2020 to July 7, 2021, 253,571 confirmed circumstances of COVID-19 and 6646 associated deaths have been reported.

Fundamental results

The median follow-up interval was 139 days, throughout which there have been 227 circumstances of SARS-CoV-2 an infection. 100 seventy-nine infections have been famous within the unvaccinated group, and the cumulative incidence was 2.8 per 10,000 person-days. The symptomatic illness developed in 131 HCWs, together with 112 within the unvaccinated group. On this case, the cumulative incidence was 1.6 per 10,000 person-days. There was appreciable heterogeneity, with the cumulative incidence within the unvaccinated group being 12.4 per 10,000 person-days and 0.3 per 10,000 person-days within the vaccinated group.

The cumulative incidence of each an infection and symptomatic illness within the two teams was considerably decrease within the vaccinated group. The vaccine efficacy was additionally estimated, and scientists noticed 9 hospitalizations, together with eight within the unvaccinated group and one within the vaccinated group. Throughout vaccination follow-up, there have been no severe and/or long-term adversarial reactions. The protection of the vaccine is the topic of a report at the moment in preparation.

Strengths and limitations

The research’s foremost strengths have been the big pattern dimension and an extended follow-up interval in comparison with others within the literature.

The principle limitation was the shortcoming to interrupt down vaccine effectiveness based mostly on age, intercourse, ethnicity, and so on. Moreover, no knowledge on the circulating virus variants have been out there. Due to this fact, these outcomes must be interpreted as these for variants much less infectious than the Delta variant. Scientists additionally opine that it might effectively be the case that some asymptomatic an infection was not detected. Lastly, the immune standing (es. immunodepression, chemotherapy therapy, and so on.) of enrolled topics was not out there.


The info offered on this evaluation are in step with the very excessive effectiveness of the BNT162b2 mRNA vaccine in stopping each SARS-CoV-2 infections. In one other research, scientists reported the manufacturing of 100% neutralizing antibodies after the second dose and well-tolerated adversarial results. After all, different research have reported low efficacy of BNT162b2 in stopping the transmission of variant B.1.1.7. The outcomes, total, ought to encourage vaccination amongst still-reluctant HCWs.

In Italy, vaccination of HCWs remains to be not obligatory, however given the severity of the pandemic, this coverage deserves severe deliberation. In March, the Italian authorities made vaccination semi-compulsory with penalties associated to wage suspension.

Nevertheless, extra analysis is required to grasp the sensible results of this regulation. Additional analysis can also be required to find out the VE of the BNT162b2 mRNA vaccine in numerous populations and over a fair longer follow-up interval. That may make folks extra comfy with the thought of vaccination and assist us fight the COVID-19 pandemic.

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