Forgotten antibiotic could also be helpful in treating extreme febrile urinary tract infections

A forgotten antibiotic, temocillin, led to decrease collection of resistant micro organism than the usual therapy for febrile urinary tract an infection, in a examine printed in The Lancet Infectious Ailments. Thus, temocillin could also be helpful in treating extreme urinary tract infections that give rise to fever, and contribute to a diminished unfold of resistant micro organism in hospitals.

Thus, temocillin could also be helpful in treating extreme urinary tract infections that give rise to fever, and contribute to a diminished unfold of resistant micro organism in hospitals.

The bacterial species Escherichia coli (E. coli) constitutes a big fraction of the traditional bacterial flora within the gut. But when E. coli will get into the mistaken locations within the physique, such because the blood or urinary tract, it may trigger severe sickness. E. coli is the commonest reason for urinary tract infections. These can usually be handled with antibiotics in pill type, however some sufferers change into so ailing that they have to be admitted to hospital and handled with intravenous antibiotics.

It has lengthy been customary process to make use of the antibiotic cefotaxime for such intravenous therapy. However as time has handed, an growing fraction of micro organism have change into much less inclined to this antibiotic, each in Sweden and the remainder of the world, and this has made it obligatory to hunt another.”


Håkan Hanberger, Professor, Linköping College

Hanberger can be a advisor in infectious ailments at Linköping College Hospital.

He has been principal investigator and medically accountable for the examine.

The examine now printed is the results of the Public Well being Company of Sweden being requested by the Swedish authorities to review how already present antibiotics can be utilized in one of the best ways. The researchers have investigated temocillin, a member of the penicillin group of antibiotics that has been identified for a number of a long time. It’s utilized in another European international locations, however shouldn’t be marketed in Sweden. Temocillin acts particularly in opposition to E. coli and different intestinal micro organism that may trigger urinary tract infections. It’s optimistic that temocillin doesn’t have a broad impact in opposition to many alternative micro organism, because it reduces the danger that the therapy will act in opposition to the traditional intestinal bacterial flora. This led the researchers to analyze whether or not temocillin offers much less resistance amongst intestinal micro organism than therapy with the usual antibiotic, cefotaxime.

They studied 152 sufferers with urinary tract an infection that gave rise to fever, also called pyelonephritis, that required intravenous antibiotics.

“We noticed clearly that the intestinal flora was much less affected within the group handled with temocillin. The principle purpose for that is that temocillin offers much less collection of resistant intestinal micro organism”, says Charlotta Edlund, professor of microbiology and specialist investigator on the Public Well being Company of Sweden.

The scientific impact of temocillin was nearly as good as the usual therapy with cefotaxime, and the undesired results have been equal. The truth that temocillin is much less aggressive in opposition to the bacterial flora within the gut means that beginning to use this forgotten antibiotic for urinary tract infections could have benefits for each sufferers and society.

“The consequence can be that we see much less collection of resistant intestinal micro organism in hospitals, which can contribute to lowering hospital-related infections from these micro organism”, says Håkan Hanberger.

Supply:

Journal reference:

Edlund, C., et al. (2021) The scientific and microbiological efficacy of temocillin versus cefotaxime in adults with febrile urinary tract an infection, and its results on the intestinal microbiota: a randomised multicentre scientific trial in Sweden. The Lancet Infectious Ailments. doi.org/10.1016/S1473-3099(21)00407-2.

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