Industrial chemical perfluorobutanoic acid much less more likely to accumulate in human lungs and kidneys

A 2013 research by Pérez et al. reported a really excessive accumulation of the economic chemical perfluorobutanoic acid (PFBA) in human lungs and kidneys. The German Federal Institute for Danger Evaluation (BfR) checked these outcomes utilizing a extra exact quantification technique. The consequence: Just one pattern contained a quantifiable PFBA worth of 0.17 nanograms (ng) per gram (g) of lung tissue. The BfR involves the conclusion that PFBA could be very unlikely to build up strongly in human lung and kidney tissue. That is supported by the brief half-life of PFBA within the blood, which was decided in one other research.

The BfR research was revealed within the Worldwide Journal of Hygiene and Environmental Well being:

Perfluorobutanoic acid – PFBA for brief – belongs to the advanced group of per- and polyfluoroalkyl substances (PFAS). PFAS are industrial chemical substances which might be extensively utilized in industrial processes and are present in quite a few client merchandise corresponding to paper, textiles, cooking pans and cosmetics. Whereas some long-chain PFAS accumulate within the human physique attributable to their lengthy half-lives, short-chain PFAS compounds corresponding to PFBA have a comparatively brief half-life within the blood. Correspondingly, blood concentrations of lower than 0.1 nanograms (ng) per millilitre (ml) had been present in a number of research.

Surprisingly, nonetheless, a 2013 research by Pérez et al. reported very excessive median concentrations of PFBA of 807 ng/g and 263 ng/g (≈ng/ml) in human lung and kidney tissue (

To confirm these outcomes, the BfR examined the PFBA content material of seven lung and 9 kidney samples from tumor operations between 2011 and 2014. The concentrations had been predominantly beneath the quantification restrict; it was solely attainable to quantify a PFBA stage of 0.17 ng/g of lung tissue in only one pattern. The nice problem within the mass spectrometric evaluation of PFBA is the presence of just one fragmentation which may result in incorrect measurements.

Subsequently, the present BfR research ( employed a high-resolution mass spectrometer that allows extra exact quantification by utilizing the precise mass. On the premise of the measurement outcomes, the BfR has concluded that PFBA is unlikely to build up excessively in human lung and kidney tissue. The BfR recommends additional research to substantiate these outcomes.

A 2020 research by Grandjean et al. reported a connection between greater PFBA blood plasma concentrations and extra extreme instances of COVID-19 ( Nevertheless, measured PFBA concentrations had been very low. The speculation that prime PFBA concentrations within the lungs may very well be the reason for the elevated severity in COVID-19 instances was put ahead on the premise of the outcomes of Pérez et al.

In view of the outcomes of the presently obtainable BfR research, such a connection is taken into account much less believable.The European Meals Security Authority (EFSA) reassessed the well being dangers posed by PFAS in meals in September 2020. On this opinion, EFSA derived a tolerable weekly consumption (TWI) of 4.4 nanograms (ng) per kilogram (kg) body weight per week (

This TWI applies for the primary time to the sum of 4 PFAS: Perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluorohexanesulfonic acid (PFHxS). It’s based mostly on an epidemiological research by which youngsters who had greater blood serum concentrations of sure PFAS had been noticed to have a decrease stage of antibody formation after ordinary vaccinations.


BfR Federal Institute for Danger Evaluation

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