Scientists at Rejuveron Vascular Therapeutics AG, an organization specializing within the improvement of therapies to sort out neurodegeneration, are utilizing INTEGRA’s VIAFLO 384 handheld digital pipette to speed up their analysis. Combining this handy benchtop system with endothelial cells cultured in Corning® HTS Transwell® 96 effectively plates permits the crew to research the flexibility of medication to penetrate the blood mind barrier (BBB).
Picture Credit score: INTEGRA
Vasco Ledebur de Antas de Campos, Head of Discovery Biology at Rejuveron Vascular Therapeutics, defined: “We deposit cells within the Transwells, and incubate them to type a monolayer on the filter membrane in every effectively. As soon as we’ve obtained excessive confluency – which simulates the BBB – we administer the drug candidates.”
“We use a VIAFLO 384 – with a 96 channel head and 125 µl Sterile Filter GripTips – to each ship the medication to the apical aspect and take samples from the basolateral aspect of the Transwells. This permits us to test the quantity of every drug that was capable of permeate the barrier. This method can be tough to carry out with an ordinary multichannel pipette, as we are sometimes screening massive libraries. In distinction, it’s a easy activity for the VIAFLO 384, since you possibly can simply program the system to aspirate from any a part of the effectively.”
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About INTEGRA Biosciences
INTEGRA Biosciences (https://www.integra-biosciences.com) is a number one supplier of high-quality laboratory instruments and consumables for liquid dealing with and media preparation. The corporate is dedicated to creating revolutionary options which fulfil the wants of its clients in analysis, diagnostics and high quality management throughout the life sciences markets and medical sector. At the moment, INTEGRA revolutionary laboratory merchandise are broadly used all world wide.
Greater than 100 distribution companions type a worldwide gross sales community offering responsive and competent companies to clients. These distribution companions are supported by a extremely motivated and skilled crew of specialists on the firm headquarters in Zizers, Switzerland and Hudson, NH, USA. INTEGRA is an ISO 9001 licensed firm.
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