bit.bio has right this moment launched a brand new product, ioSkeletal Myocytes. It’s the primary product of its sort that gives physiologically related human skeletal muscle cells which might be dependable, reproducible and constant at scale. Entry to ioSkeletal Myocytes will supercharge analysis and drug discovery for musculoskeletal and metabolic situations.
Picture Credit score: bit.bio
ioSkeletal Myocytes can be utilized inside days after thawing, affording scientists unprecedented ease and consistency for his or her experiments. ioSkeletal Myocytes are created by means of direct reprogramming of human iPSCs (induced pluripotent stem cells) utilizing bit.bio’s breakthrough cell coding know-how opti-ox™. They’re the second ‘off the shelf’ cell sort product from bit.bio and type a part of the increasing ioCells portfolio.
This second product is one other validation of bit.bio’s strategy to biology as the subsequent disruptive know-how. Once you give scientists entry to dependable human cells the one restrict to the questions they will ask and the experiments they will design is their creativeness. And we’re already seeing that creativeness unleashed within the various methods our companions are utilizing our cells.
Every ioCell will open up a complete new product line within the type of illness fashions, offering even larger analysis alternatives. Constructing out our ioCell portfolio is a core pillar of bit.bio’s technique, subsequent to creating bit.bio’s cells for therapeutic functions. Collectively, this may allow the subsequent technology of medicines.”
Dr Mark Kotter
ioSkeletal Myocytes have been validated by bit.bio’s companions in numerous functions, a key stage within the improvement of the product. One companion, Charles River Laboratories, a supplier of services that assist expedite the invention, early-stage improvement and secure manufacture of novel medicine and therapeutics, has adopted bit.bio’s ioSkeletal Myocytes into its discovery providing, together with high-throughput screening (HTS) workflows.
Beforehand, buying skeletal myocytes for analysis has both been from animal fashions, which don’t at all times behave like human muscle cells, or through the use of main human cells with strategies that produce solely small cell portions.
We have now seen first-hand that ioSkeletal Myocytes get rid of this cumbersome, time-consuming course of, and rapidly present dependable and constant entry to massive portions of human myocytes, which can be utilized for high-throughput screening.”
Dr Marijn Vlaming
The product gives purposeful and constant human cells which can be utilized to review the physiology of human skeletal muscle cells and their response to potential drug candidates.
bit.bio’s human ioSkeletal Myocytes will enhance translatability of analysis findings so can play a big position in decreasing the typical price and time spent on drug improvement and enhance the possibilities of new remedies making it by means of the clinic and to sufferers.
ioSkeletal Myocytes are launching forward of a bit.bio workshop at The European Laboratory Analysis & Innovation Group (ELRIG) drug discovery convention the place audio system Dr Luckshman Jeremy Anton (Charles River Laboratories), Prof Michael Duchen (College Faculty London) and Prof Hagan Bayley (College of Oxford) will focus on the challenges of cell fashions and novel approaches and instruments for fundamental analysis and drug discovery that embody bit.bio’s cells.
ioSkeletal Myocytes can be found by means of bit.bio and affiliated distributions to the larger educational and biotech communities.
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