JPND declares name for multinational analysis on understanding the mechanisms of non-pharmacological interventions

The EU Joint Programme – Neurodegenerative Illness Analysis (JPND) initiative has introduced a joint transnational name for multinational analysis on understanding the mechanisms of non-pharmacological interventions.

Neurodegenerative ailments are debilitating and largely untreatable circumstances which might be strongly linked to age. Worldwide, there are estimated to be 50 million individuals affected by Alzheimer’s illness and associated issues, the most typical class of neurodegenerative ailments. Current therapies for neurodegenerative ailments are restricted in impact and primarily handle the signs relatively than the trigger or the progressive course.

A number of non-pharmacological interventions have been proven to be efficient and accepted by sufferers. Such interventions could embody, amongst others, psychosocial interventions, neuromodulation, diet or train. Though neurodegenerative ailments are recognised as multifactorial syndromes, there’s little interplay between biomedical and psychosocial approaches. One rationale for integrating biomedical and psychosocial analysis is the discordance between neuropathology and cognitive functioning. Nonetheless, there’s but little information in regards to the mechanisms of non-pharmacological interventions, e. g. on the molecular or mobile degree. With this in thoughts, JPNDhas recognized a urgent want for investmentaimed at enabling analysis initiatives on understanding the mechanisms of non-pharmacological interventions.

In partnership with the European Fee, JPND is inviting multinational analysis groups to submit proposals for formidable, progressive and multidisciplinary collaborative analysis initiatives aimed toward understanding the biomedical, psychological and/or social mechanisms of non-pharmaceutical interventions with a purpose to establish potential goal websites for enhanced customized interventions or a mix of pharmacological and non-pharmacological interventions.

Proposals should deal with one or a number of of the next neurodegenerative ailments:

  • Alzheimer’s illness and different dementias
  • Parkinson’s illness and PD‚Äźassociated issues
  • Prion ailments
  • Motor neuron ailments
  • Huntington’s illness
  • Spinocerebellar ataxia (SCA)
  • Spinal muscular atrophy (SMA)

Proposals submitted beneath this name could embody, however should not restricted to, the next kinds of analysis:

  • Figuring out biomolecular and/or bodily underpinnings of results of non-pharmacological interventions;
  • Analyzing the mechanisms of efficient non-pharmacological interventions on the molecular and mobile degree by making use of cutting-edge applied sciences;
  • Identification of the mechanisms of non-pharmacological interventions throughout the mind, utilizing mind imaging, electrophysiology and different equal state-of-the-art strategies;
  • Identification of organic, psychological and social well being markers and their associations to permit the identification of modifiable threat elements amenable to non-pharmacologicalinterventions and higher predict and monitor the results of those interventions for future large-scale medical research;
  • Elaborating modified ideas of non-pharmacological interventions with enhanced efficacy based mostly on a deeper understanding of the mechanisms;
  • Identification of potential drug-target websites for a mix of pharmacological and non-pharmacological interventions;
  • Discovering (particular person) elements that predict response to interventions.

Pre-proposals should be submitted by the coordinator in digital format no later than 12:00h (midday) C.E.T. on March 1, 2022.


EU Joint Programme – Neurodegenerative Illnesses Analysis (JPND)

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