Lengthy-term use of blood stress remedy may very well be contributing to kidney harm

New kidney analysis from the College of Virginia Faculty of Medication is elevating issues that long-term use of medication generally prescribed to deal with high-blood stress and coronary heart failure may very well be contributing to kidney harm.

Sufferers ought to proceed taking the drugs, which embody the well-known and broadly used ACE inhibitors, the researchers say. However the scientists are urging research to raised perceive the medicine’ long-term results.

Our research present that renin-producing cells are accountable for the harm. We at the moment are specializing in understanding how these cells, that are so vital to defend us from drops in blood stress and preserve our well-being, bear such transformation and induce kidney harm. What is required is to establish what substances these cells make that result in uncontrolled vessel progress.”


Maria Luisa Sequeira Lopez MD, UVA’s Division of Pediatrics and Little one Well being Analysis Heart

The causes of kidney harm

Continual hypertension impacts a billion folks around the globe. The UVA researchers wished to raised perceive why extreme types of the situation are sometimes accompanied by thickening of the arteries and small blood vessels within the kidney, resulting in organ harm.

They discovered that specialised kidney cells referred to as renin cells play an vital position. These cells usually produce renin, a significant hormone that helps the physique regulate blood stress. However dangerous modifications within the renin cells may cause the cells to invade the partitions of the kidney’s blood vessels. The renin cells then set off a buildup of one other cell kind, easy muscle cells, that trigger the vessels to thicken and stiffen. The end result: Blood cannot movement by means of the kidney because it ought to.

Additional, the researchers discovered, long-term use of medication that inhibit the renin-angiotensin system, comparable to ACE inhibitors, or angiotensin receptor blockers, have the same impact. These medicine are broadly used for a lot of functions, together with treating hypertension, congestive coronary heart failure and coronary heart assaults, in addition to to stop main coronary heart issues. However long-term use of the medicine was related to hardened kidney vessels in each lab mice and people, the scientists discovered.

The researchers be aware that the drugs will be lifesaving for sufferers, in order that they stress the significance of constant to take them. However they are saying extra research are wanted to raised perceive the medicine’ long-term results on the kidneys.

“It might be vital to conduct potential, randomized managed research to find out the extent of practical and tissue harm in sufferers taking drugs for blood stress management,” mentioned Ariel Gomez, MD, of UVA’s Division of Pediatrics and Little one Well being Analysis Heart. “It’s crucial to search out out what molecules these cells make in order that we will counteract them to stop the harm whereas the hypertension is handled with the present medicine out there at present.”

Findings printed

The researchers have printed their findings within the scientific journal JCI Perception. The article was chosen as a canopy story. The analysis staff consisted of Hirofumi Watanabe, Alexandre G. Martini, Evan A. Brown, Xiuyin Liang, Silvia Medrano, Shin Goto, Ichiei Narita, Lois J. Arend, Sequeira-Lopez and Gomez.

The analysis was supported by the Nationwide Institutes of Well being, grants P50 DK 096373, R01 DK 116718, R01 DK 116196, R01 DK 096373 and R01 HL 148044; and the Japan Society for the Promotion of Science Abroad Analysis Fellowships.

Supply:

College of Virginia Well being System

Journal reference:

Watanabe, H., et al. (2021) Inhibition of the renin-angiotensin system causes concentric hypertrophy of renal arterioles in mice and people. JCI Perception. doi.org/10.1172/jci.perception.154337.

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