Making a timeline that particulars the earliest COVID-19 instances in Wuhan

In a Perspective, Michael Worobey gives an outline of the essential occasions that occurred between December 2019 and January 2020 in Wuhan, China, making a timeline detailing the earliest instances of COVID-19, their connections to the Hunan Market the place reside animals have been bought, and the occasions that led to SARS-CoV-2’s formal identification as a novel virus. He attracts on myriad sources – together with the scientific literature and up to date reporting within the press – to develop his timeline.

In line with Worobey, many of the first instances of the virus have been related to the Hunan market, suggesting that zoonotic spillover on the live-animal market was the possible supply of COVID-19. Sadly, no reside mammal collected from Wuhan’s live-animal market has been screened for SARS-CoV-2-related viruses and Hunan Market was closed and disinfected quickly after the symptomatic instances started to rise. Regardless of this, Worobey notes that many of the early symptomatic instances have been linked to Hunan Market, and particularly the western part the place animals recognized to be prone to coronaviruses have been caged.

“Though it might by no means be attainable to recuperate associated viruses from animals in the event that they weren’t sampled on the time of emergence, conclusive proof of a Huanan Market origin from contaminated wildlife could nonetheless be obtainable via evaluation of spatial patterns of early instances and from extra genomic information, together with SARS-CoV-2 optimistic samples from Hunan Market, in addition to via integration of extra epidemiologic information,” write the authors. “Stopping future pandemics relies on this effort.”

Supply:

American Affiliation for the Development of Science (AAAS)

Journal reference:

Worobey, M., (2021) Dissecting the early COVID-19 instances in Wuhan. Science. doi.org/10.1126/science.abm4454.

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