Marshall College researcher awarded $1.36 million NIH grant for kidney-related examine

Sandrine V. Pierre, Ph.D., affiliate professor of biomedical sciences on the Marshall College Joan C. Edwards College of Drugs and interim director of the Marshall Institute for Interdisciplinary Analysis (MIIR), has been awarded a Analysis Challenge Grant (R01), one of the aggressive grants issued by the Nationwide Institutes of Well being (NIH).

Pierre was awarded the $1.36 million, four-year grant (R01DK129937) from the Nationwide Institute of Diabetes and Digestive and Kidney Ailments to review the regulatory mechanism of salt dealing with by the kidney and malfunction of this mechanism that compromises the physique’s potential to take away salt. The brand new examine will draw upon the famend experience of Marshall investigators on the signaling and scaffolding operate of the Na/Ok-ATPase protein and its influence on cardiovascular operate.

The mishandling of salt stability by the physique contributes to the event and development of many frequent ailments, together with hypertension and organ injury as a result of failure to take away extra quantity of salt. Subsequently, the proposed investigation has profound fundamental and medical implications and might also present new targets for creating higher therapeutics.”

Sandrine V. Pierre, Ph.D., Affiliate Professor of Biomedical Sciences, Marshall College Joan C. Edwards College of Drugs

Pierre will work with a workforce of researchers throughout the Joan C. Edwards College of Drugs with experience in renal physiology and preclinical research of Na/Ok-ATPase receptor operate.

Pierre joined the Marshall school in 2014. She has a doctorate in mobile and molecular endocrinology from Aix-Marseille II College in France. Previous to becoming a member of Marshall, she was on the school of the College of Toledo School of Drugs. A big a part of her analysis has centered on the signaling operate of the Na/Ok-ATPase and its therapeutic functions in cardiovascular ailments with help from the American Coronary heart Affiliation and the Nationwide Coronary heart, Lung and Blood Institute.

The R01 is the unique and traditionally oldest grant mechanism utilized by NIH. The R01 offers help for health-related analysis and growth primarily based on the mission of the NIH.


Marshall College Joan C. Edwards College of Drugs

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