Medical employees with a historical past of allergy suffered hostile reactions to BNT162b2 COVID-19 vaccine

Scientists have claimed that the continuous unfold of extreme acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus can solely be contained via speedy vaccination. SARS-CoV-2 is a positive-stranded RNA virus that has induced the coronavirus illness (2019) pandemic. Researchers worldwide labored at an unprecedented velocity to develop vaccines and therapeutics to comprise the continued pandemic. A number of vaccines have obtained emergency use authorization (EUA) from varied regulatory our bodies, whereas others are present process medical trials.

Study:Adverse reactions to BNT162b2 mRNA COVID-19 vaccine in medical staffs with a history of allergy. Image Credit: Neeila/ ShutterstockExamine: Hostile reactions to BNT162b2 mRNA COVID-19 vaccine in medical staffs with a historical past of allergy. Picture Credit score: Neeila/ Shutterstock

The BNT162b2 vaccine, developed by Pfizer-BioNTech, was the primary accessible mRNA vaccine in Japan in February 2021. In keeping with the medical trials, BNT162b2 was 95% efficient in stopping symptomatic COVID-19 an infection in vaccinated people. Though the healthcare employees (HCW) have been the primary to be vaccinated, the rise within the availability of many different accepted vaccines enhanced the speed of vaccination among the many common inhabitants.

COVID-19 vaccines and hostile reactions

Though vaccination is the best means to handle SARS-CoV-2 an infection, all of the accepted vaccines have proven sure hostile reactions. The commonest hostile reactions are ache on the web site of vaccination, fever, and a few allergic signs. Nevertheless, a extra severe hostile response can also be related to vaccination, the event of anaphylaxis, a life-threatening situation.

As COVID-19 vaccines are new, there are lots of unknown elements. As an example, it’s unknown if a person will develop an allergy or extreme anaphylaxis after being vaccinated. It has been extraordinarily troublesome to find out if a person with allergy symptoms must be vaccinated. It is because, within the medical trials, which consider the protection of a vaccine, people with a historical past of allergy have been excluded. To this point, a restricted variety of research can be found that assess the protection of COVID-19 vaccines in people with a historical past of allergy symptoms.

Analysis of the protection of the BNT162b2 vaccine for people with allergy symptoms

Scientists have addressed the hole within the analysis relating to the hostile reactions to the COVID-19 vaccine amongst people with allergy symptoms. They revealed their findings on the medRxiv* preprint server. The present research was carried out at Yamagata College Hospital, Japan, the place the BNT162b2 mRNA COVID-19 vaccine was administered to hospital employees and medical college students between March 3, 2021, and August 27, 2021.

The authors of this research carried out a survey to find out (a) if any of the vaccinated well being care employees and medical college students had a historical past of allergy and (b) hostile reactions after immunization amongst them. Subsequently, researchers analyzed the info and verified the protection of the COVID-19 vaccine amongst this group.

On this research, researchers circulated the questionnaire to their topics after receiving the primary and second doses of the vaccine. The individuals have been requested if that they had a historical past of allergy symptoms, and in case of any, the character of the allergy was requested to be reported. Additional, they have been requested in the event that they skilled any hostile reactions post-immunization and, if any, the length and all particulars related to it.

Researchers obtained responses from 1586 individuals after the primary vaccination and 1306 individuals after the second dose of the BNT162b2 vaccine. After analyzing the info, scientists revealed that some widespread hostile reactions equivalent to ache and swelling on the vaccination web site, fever, fatigue, headache, nausea, chills, arthralgia, and muscle ache exterior the vaccination web site prevailed. Usually, the frequency and severity of probably the most hostile reactions have been discovered after the second vaccination dose than the primary. Additionally, apparently, this research revealed that females and youthful people skilled hostile reactions at a better fee than males and the aged.

The current research reported that the themes with a historical past of allergy symptoms skilled some hostile reactions with larger severity, and the length of signs lasted for an extended interval in comparison with topics with none allergy symptoms. This end result agrees with a earlier research that reported COVID-19 vaccination of hospital employees confirmed a better frequency of hostile reactions within the presence of allergy.

Most significantly, although some individuals needed to go to an emergency room for therapy after receiving the primary or second dose of the vaccine, none skilled anaphylaxis. This end result indicated that no severe life-threatening allergic reactions occurred among the many topics, regardless of having a historical past of allergy, publish the BNT162b2 vaccination.


This research has a number of limitations. As an example, this survey was an internet-based questionnaire, and all of the signs have been self-reported. Thereby, it isn’t clear if the analysis of the allergic reactions was right. Additionally, only a few topics had a historical past of anaphylaxis or hostile allergic response, so the statistical reliability of the info was not sturdy. Nevertheless, the authors of this research beneficial vaccination for people with a historical past of allergy as no severe hostile response surfaced among the many topics after immunization.

*Essential Discover

medRxiv publishes preliminary scientific reviews that aren’t peer-reviewed and, subsequently, shouldn’t be considered conclusive, information medical observe/health-related conduct, or handled as established info.

Journal reference:

  • Inoue, S. et al. (2021) “Hostile reactions to BNT162b2 mRNA COVID-19 vaccine in medical staffs with a historical past of allergy”. medRxiv. doi: 10.1101/2021.09.13.21263473.

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