New report on 1.23 million breakthrough symptomatic SARS-CoV-2 infections by vaccine

A number of vaccines have been developed in opposition to the extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to curb the continuing coronavirus illness 2019 (COVID-19) pandemic. As of December 28, 2021, the USA Facilities for Illness Management and Prevention (CDC) have reported a minimum of 77.6% of the U.S. inhabitants over the age of 5 have obtained a minimum of one dose of the COVID-19 vaccine.

A brand new analysis letter revealed in JAMA Community Open evaluates whether or not the estimated vaccine effectiveness modifications in opposition to an infection over time in an effort to assist inform public well being coverage and medical practices.

Study: Incidence and Estimated Vaccine Effectiveness Against Symptomatic SARS-CoV-2 Infection Among Persons Tested in US Retail Locations, May 1 to August 7, 2021. Image Credit: vovidzha /

Research: Incidence and Estimated Vaccine Effectiveness In opposition to Symptomatic SARS-CoV-2 An infection Amongst Individuals Examined in US Retail Places, Could 1 to August 7, 2021. Picture Credit score: vovidzha /

In regards to the examine

The present case-control examine adopted the Strengthening the Reporting of Observational Research in Epidemiology (STROBE) reporting guideline. The examine used a nationwide SARS-CoV-2 database to guage distinctive sufferers who have been symptomatic for SARS-CoV-2 an infection.

Optimistic SARS-CoV-2 infections have been confirmed utilizing polymerase chain response (PCR) assessments. Information for the examine have been collected from Could 1, 2021, to August 7, 2021.

The examine contributors answered a screening questionnaire that included questions relating to COVID-19–associated signs per CDC definition, vaccination standing, variety of doses, and vaccination time earlier than assortment of nasal swabs. BNT162b2 (Pfizer), mRNA-1273 (Moderna), and JNJ-78436735 (Johnson & Johnson) vaccines have been used for evaluation. SARS-CoV-2 detrimental instances have been used as controls to find out the effectiveness of the vaccines.

Individuals had a minimum of 1 self-reported symptom per US Facilities for Illness Management and Prevention (CDC) definition (fever, shortness of breath, cough, chills, nausea or vomiting, muscle ache, sore throat, lack of style or odor, fatigue, headache, congestion, diarrhea). Vaccinated individuals included all receiving any variety of doses of any of the three vaccines (for mRNA vaccines, 99.9% of individuals reported receiving 2 doses). Information on Delta virus proportions have been obtained from the CDC web site.

Research findings

The outcomes indicated that out of the 1,237,097 people included within the examine, 59.2% have been ladies, 40.7% have been males, and 0.1% have been unknown. The examine additionally concerned numerous teams that included Asians, Black or African Individuals, White, Hispanic, Alaska Natives, Pacific Islanders, and American Indian people. Of the vaccinated people, 27.1% obtained the BNT162b2 vaccine, 16.8% obtained the mRNA-1273 vaccine, and 4% obtained the JNJ-78436735 vaccine.

The outcomes reported that people who obtained the messenger ribonucleic acid (mRNA) vaccines had the bottom incidence fee, whereas unvaccinated people had the very best. The unvaccinated people have been discovered to have 412%, 287%, and 159% extra infections as in comparison with those that had obtained the mRNA1273, BNT162b2, or JNJ-78436735 vaccines, respectively.

Fashions have been adjusted for age, geographic area, and calendar month of take a look at. Estimated vaccine effectiveness over time because the remaining dose was calculated as (1 − multivariable-adjusted odds ratio for an infection) × 100. The ultimate dose was outlined as the one dose for JNJ-78436735 and the second dose for mRNA-1273 or BNT162b2 earlier than August 7, 2021.

The incidence fee was noticed to be 24.8% for unvaccinated people, 15.6% for these receiving the JNJ-78436735 vaccine, 8.6% for the BNT162b2 vaccine, and 6% for the mRNA1273 vaccine. The magnitude of SARS-CoV-2 an infection was noticed to be even increased for unvaccinated people through the prevalence of the Delta pressure.

The vaccine effectiveness for individuals who had obtained two doses of the mRNA vaccines peaked after two weeks then fell to 86.8% in two to 3 months and additional to 74.2% after six months. For one dose of JNJ-78436735, vaccine effectiveness was discovered to be better than 50% after two weeks.


The present examine supplied real-world proof on the chance of unvaccinated people in opposition to SARS-CoV-2. Unvaccinated people have been 4 instances extra more likely to contract COVID-19 as in comparison with vaccinated people. Subsequently, unvaccinated people are suggested to get vaccinated, because it is not going to solely defend them but in addition the neighborhood in opposition to extreme SARS-CoV-2 infections.


The present examine had two main limitations. First, because the vaccination statuses have been self-reported, there have been possibilities of errors and lacking knowledge. Second, the info for the examine have been collected at retail settings, which makes it more likely to symbolize lesser extreme infections than these recognized in inpatients.

Journal reference:

  • Tabak, Y. P., Solar, X., & Brennan, T. A., et al. (2021). Incidence and Estimated Vaccine Effectiveness In opposition to Symptomatic SARS-CoV-2 An infection Amongst Individuals Examined in US Retail Places, Could 1 to August 7, 2021. JAMA Community Open. doi:10.1001/jamanetworkopen.2021.43346.

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