Researchers untangle dopamine’s various features

Among the many neurotransmitters within the mind, dopamine has gained an nearly legendary standing. Many years of analysis have established its contribution to a number of seemingly unrelated mind features together with studying, motivation, and motion, elevating the query of how a single neurotransmitter can play so many various roles.

Untangling dopamine’s various features has been difficult, partially as a result of the superior mind of people and different mammals comprise completely different sorts of dopamine neurons, all embedded in extremely advanced circuits. In a brand new research, Rockefeller’s Vanessa Ruta and her workforce dive deep into the query by wanting as an alternative on the a lot less complicated mind of the fruit fly, whose neurons and their connections have been mapped intimately.

As in people, a fly’s dopamine neurons present a sign for studying, serving to them to hyperlink a specific odor to a specific final result. Studying that, for instance, apple cider vinegar incorporates sugar serves to form the animals’ future conduct on their subsequent encounter with that odor. However Ruta’s workforce found that the identical dopamine neurons additionally correlate strongly with the animal’s ongoing conduct. The exercise of those dopamine neurons doesn’t merely encode the mechanics of motion, however fairly seems to replicate the motivation or purpose underlying the fly’s actions in actual time. In different phrases, the identical dopamine neurons that educate animals long-term classes additionally present moment-to-moment reinforcement, encouraging the flies to proceed with a useful motion.

“There appears to be an intimate connection between studying and motivation, two completely different aspects of what dopamine does,” says Ruta, who printed the findings in Nature Neuroscience.

Steady studying

Smells are vital to flies. A mind middle for olfactory studying, referred to as the mushroom physique, is accountable for educating them which smells signify tasty sugar. There, three varieties of neurons come collectively: Kenyon cells that reply to odors, the output neurons that ship indicators to the remainder of the mind, and the dopamine-producing neurons. When the fly encounters an odor after which will get a sugar reward, a fast launch of dopamine alters the energy of connections between neurons of the mushroom physique, primarily serving to the fly to make new associations and alter its future response to that odor.

However Ruta and her colleagues have seen ongoing dopamine signaling even within the absence of rewards. The identical neurons that helped the flies be taught associations additionally fired steadily because the animal moved.

That raised the query, are these neurons representing particular points of the motion, like how the animal is transferring its legs, or are they associated to one thing else, just like the purpose of the animal?”


Vanessa Ruta, Rockefeller College

To seek out out, the workforce developed a virtual-reality system through which fruit flies can navigate an olfactory setting, strolling on a treadmill-like ball whereas their mind exercise is monitored by a microscope over their head. A stream of air delivers odors by a small tube. When the fly will get a whiff of a pretty odor, like apple cider vinegar, it reorients and begins to maneuver upwind, in direction of the supply.

Utilizing this technique, the researchers had been in a position to look at the fly’s mind exercise below completely different circumstances. They discovered that the exercise of dopamine neurons intently displays actions as they had been taking place, however solely when the flies have interaction in purposeful monitoring, and never when they’re simply wandering about.

When the researchers suppressed the exercise of the dopamine neurons, the animals diminished their monitoring of the odor, even once they had been ravenous and subsequently had a heightened curiosity in food-related smells. In distinction, activating the neurons in food-indifferent, absolutely fed flies, propelled them into lively pursuit of the odor.

Collectively, the findings reveal how one dopamine pathway can carry out two features: conveying motivational indicators to quickly form ongoing behaviors whereas additionally offering instructive indicators to information future conduct by studying. “It offers us a deeper understanding of how a single pathway can generate completely different types of versatile conduct,” Ruta says.

The following step is to grasp how the opposite neurons know what a burst of dopamine means at any given time. One chance, Ruta says, is that studying is a extra steady, dynamic course of than usually thought: On brief timescales, animals constantly consider their conduct at each step, studying not simply the ultimate associations, but in addition the actions that lead them there.

Supply:

Journal reference:

Zolin, A., et al. (2021) Context-dependent representations of motion in Drosophila dopaminergic reinforcement pathways. Nature Neuroscience. doi.org/10.1038/s41593-021-00929-y.

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