USC Stevens INI launches a $3 million research to unravel some puzzles about Parkinson’s illness

The USC Mark and Mary Stevens Neuroimaging and Informatics Institute (USC Stevens INI), a part of the Keck College of Medication of USC, has launched a $3 million research that can unite researchers and knowledge from 20 nations to reply among the most urgent questions on Parkinson’s illness (PD). The 5-year collaborative effort, referred to as ENIGMA-PD, will analyze mind imaging, genetics, and medical knowledge in one of many world’s largest research of the illness.

This new grant will deal with among the main puzzles about how PD progresses within the mind, and the way remedy can shield towards these adjustments.”

Paul M. Thompson, PhD, principal investigator of the brand new initiative and affiliate director, USC Stevens INI

The researchers have already carried out one of many largest internationally coordinated analyses of PD mind imaging knowledge. They studied structural variations between 1,182 wholesome brains and a couple of,357 affected by PD, figuring out a attribute sample of tissue harm that started within the mind’s temporal lobes and spreads all through the cortex. These findings problem the standard knowledge about PD, which holds that deeper areas of the mind are broken first and should trace at a number of PD subtypes with totally different programs and coverings. The research was revealed within the journal Motion Issues in July.

ENIGMA-PD will research whether or not remedies, together with medicine similar to L-Dopa and surgical therapies similar to Deep Mind Stimulation, can decelerate this development of mind tissue loss and medical decline. Researchers will even examine genetic elements that contribute to PD danger, with a selected concentrate on how totally different genes improve the chance of growing PD in people with European versus Asian ancestry.

“What’s distinctive about this mission is that it engages consultants from throughout the globe, which will probably be essential for understanding how Parkinson’s danger and development might differ relying on an individual’s genetic background,” mentioned Thompson, who can be a professor of ophthalmology, neurology, psychiatry and the behavioral sciences, radiology and engineering on the Keck College of Medication.

The grant funds researchers who’re gathering knowledge in traditionally understudied areas, together with Taiwan, South Africa, and Siberia. Thompson will lead the hassle at the side of Kathleen Poston, MD, of Stanford College and Ysbrand van der Werf, PhD, of Amsterdam College Medical Facilities within the Netherlands.

ENIGMA-PD builds on the success of the Enhancing Neuro Imaging Genetics by means of Meta-Evaluation (ENIGMA) consortium, which unites neuroimaging researchers in 45 nations to review a spread mind illnesses and processes. Based in 2009, the ENIGMA community has carried out among the world’s largest neuroimaging research of schizophrenia, bipolar dysfunction, main melancholy, epilepsy, and different circumstances affecting the mind.

The mission provides to the INI’s ongoing work on PD, which started in 2010 with the launch of the Parkinson’s Development Markers Initiative (PPMI). The institute shops all of the medical, genetic and imaging knowledge for greater than 1,400 people within the PPMI research, which is sponsored by the Michael J. Fox Basis.

“PPMI has already superior the vital seek for biomarkers of Parkinson’s illness,” mentioned Arthur W. Toga, PhD, provost professor of ophthalmology, neurology, psychiatry and the behavioral sciences, radiology and engineering, the Ghada Irani Chair in Neuroscience on the Keck College and director of the INI. “ENIGMA-PD will amplify these efforts and assist us proceed to enhance the prognosis for these dwelling with PD.”


Keck College of Medication of USC

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