Vitamin C deficiency related to cognitive impairment amongst older hospitalized sufferers

Cognitive impairment amongst older hospitalized Australians may very well be the results of low vitamin C ranges, a Flinders College-led examine has discovered, paving the way in which for a possible remedy.

Vitamin C deficiency associated with cognitive impairment among older hospitalized patients

Picture Credit score: Flinders College

Widespread in older hospitalized sufferers, cognitive impairment can lead to an individual having hassle remembering issues, concentrating or making choices.

“Earlier analysis has proven that vitamin C performs a big position within the functioning of the mind, with research discovering that vitamin C deficiency could also be related to cognitive impairment, melancholy and confusion,” says lead creator Affiliate Professor Yogesh Sharma from Flinders College’s School of Medication and Public Well being.

160 sufferers aged over 75 admitted to the Geriatric Analysis and Administration Unit on the Flinders Medical Centre in Adelaide, the analysis crew assessed their cognitive operate and vitamin C ranges.

A complete of 91 sufferers (56.9%) have been discovered to have cognitive impairment, whereas 42 (26.3%) have been discovered to be vitamin C poor with a stage under 11 micromol/L, under which level scurvy might develop.

Our findings confirmed that cognitive operate scores have been considerably decrease amongst sufferers who have been vitamin C poor, with additional evaluation suggesting vitamin C deficiency was virtually 3 instances extra prone to be related to cognitive impairment after adjustment for different components.”

Yogesh Sharma, Affiliate Professor, Flinders College’s School of Medication and Public Well being

The examine additionally discovered that the signs related to scurvy have been prone to be current amongst sufferers with or with out vitamin C deficiency. Many of those signs of vitamin C deficiency are frequent in older individuals, who could have bleeding, bruising and pores and skin points as a consequence of plenty of different situations.

“It could, subsequently, be tough to diagnose vitamin C deficiency solely on searching for these explicit signs in older hospitalized sufferers,” says Affiliate Professor Sharma.

“Given we all know vitamin C deficiency is frequent amongst older hospitalized sufferers, medical professionals want to stay vigilant for this situation and make sure a affected person’s vitamin C standing in suspected circumstances.”

The authors say whereas the examine doesn’t show that vitamin C is a direct reason for the cognitive impairment, it has demonstrated that vitamin C deficiency is frequent and is related to cognitive impairment in older hospitalized sufferers.

“Additional research can be wanted to verify this hyperlink after which we will look to ascertain whether or not vitamin C substitute could also be useful in prevention or reversal of the cognitive impairment,” says co-author Professor Campbell Thompson from the College of Adelaide.


Journal reference:

Sharma, Y., et al. (2022) Relationship between Vitamin C Deficiency and Cognitive Impairment in Older Hospitalised Sufferers: A Cross-Sectional Examine. Antioxidants.

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